The perfusion making process of the relief type stereo artwork includes: computer aided making of effect photograph; carving the stereo model with fatlute; making model with silicon gel mixture comprising silicon gel, hardening agent, etc. as demolding material; perfusing with semi-hard resin; coloring; coating the perfused article with unsaturated resin; making a telescopic binder to jacket the article and fastening to certain degree for heat transfer; heating to deform in controlled state; and cooling to form the relief type stereo artwork. The present invention has the advantages of low making cost, no deformation, no color change, high transparency and high artistic effect.