The present invention relates to a method of configuring and operating pre-printing work flow, and belongs to the field of pre-printing technology. The available technology has relatively fixed work flow and operating mode and limited work flow altering technology. The method of the present invention includes the corresponding between resource and treatment and the designation of priority level to constitute iterative work flow model with multiple inputs and outputs and high concurrence. Adopting the method of the present invention has processor not limited to the single input of tree work flow, new created resource not limited to the post-treatment of tree flow, obviously raised work flow configuration and operation flexibility and raised processing efficiency.