The method includes steps: comparing optical disk read signal with a preset reference signal to obtain multiple signal values relevant between the optical read signal and the reference signal, the said correlative signal values are accorded with a preset condition; sampling optical disk read signal to obtain multiple sampled signal values; based on the said signal values and the said sampled signal values, capturing two adjacent sampled values for said each signal value; finally, based on corresponding preset relation between mean value of difference values of two adjacent sampled values for said each signal value and maximum value in difference values, the disclosed method determines quality of optical disk read signal. The invention determines quality of optical disk read signal from larger range, and determines quality of signal in asynchronism domain so as to overcome disadvantages in existed technique.