The present invention relates to one kind of composite medicine for treating tumor and its application. The composite medicine includes rapamycin or its derivative, matrine or curcumin, etc as the antitumor matters, and may be prepared into oral solid preparation or injection. The solid preparation includes core of matrine or curcumin and coating medicine of rapamycin and taxol. The composite medicine injection contains rapamycin of 1-30 mg/ml concentration, matrine or curcumin of 5-300 mg/ml concentration and taxol of 0-50 mg/ml concentration. The composite medicine has the synergistic effect of the antitumor active components and has raised curative effect.