The invention relates to a 4, 4-disubstitutional-3,4-dihydro-2(one hydro)-quinaldinicketones compound and its method for synthesizing and its application. The said compound can be a compound with constitutional formula thereof as following, or its stereoisomer, its stereoisomeric mixture or a salt which can be accepted in the pharmacy. The method for synthesizing chiral pure isomer is carried out mainly by the asymmetric additive reaction between substrates of methyl ketone and trifluoromethylketone imine. Additionally, we can construct the most critical trifluoromethyl quaternary carbon chiral center of the target compound DPC083 easily and efficiently. Afterwards, the synthesis of the target compound DPC083 is realized by the transformation of the function group.