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发明公开
CN1837367A 针对乙型流感病毒膜蛋白基因的siRNA序列及其应用 失效 - 权利终止

针对乙型流感病毒膜蛋白基因的siRNA序列及其应用
摘要：
本发明涉及一组针对乙型流感病毒膜蛋白编码基因的siRNA及其制备方法和应用。选取乙型流感病毒膜蛋白(M)编码基因中高度保守的序列作为siRNA的靶序列，并且以靶序列中的连续10－30(优选，15－27，更优选19－23)bp的序列设计siRNA。细胞和动物模型攻毒实验证明，以乙型流感病毒基因组中高度保守的序列作为靶序列，应用能与靶序列特定位点上的核苷酸序列互补配对的siRNA，可以阻断该基因在细胞和动物模型中的复制与表达，从而有效地抑制不同乙型流感病毒毒株在细胞和动物模型的复制与感染，以达到治疗流行性感冒的目的。
摘要（英）：

The invention discloses a siRNA sequence and appliance of influenza B virus membrane protein gene M, which is characterized by the following: selecting the high-degree conservative sequence in the M coding gene as siRNA target sequence; designing siRNA at continual 10-30 (15-27 better, 19-23 much better) in the target sequence; applying the siRNA of ribotide sequence complementary mate with target sequence; blocking the duplication and expression of the gene in the cell and animal model; inhibiting different influenza B virus crops from duplicating and infecting among cell and animal models; reaching the goal to cure influenza.

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