The present invention discloses a method for producing alcohol from mixed microbial pool degradable and fermented lignocellulose substance, relating to a method for producing alcohol by degradation of fermented lignocellulose substance, and solves the problems of high cost and long production cycle in production of alcohol by using the lignocellulose substance in the prior art. The method comprises the following steps: 1) crushing lignocellulose substance, soaking with H2SO4, and bursting by steam; 2) solid-liquid separating, adding nutritive liquid into solid-phase substance, and sterilizing; 3) adding distiller's yeast and cellulose degrading microbe into saccharifying fermentative substrate; 4) degradation saccharifying-fermenting synchronously, distilling and rectifying to obtain final product. The method for producing alcohol from mixed microbial pool degradable and fermented lignocellulose substance provided by the present invention has the advantages that: degradation and saccharification-fermentation are synchronously occurred, thus the degradation and saccharification-fermentation period is shortened by 40% while the productive technology is simplified and the use ratio of equipment is improved. Moreover, the feedback inhibition function to cellulose hydrolysis of monose is eliminated and both the raw material utilization rate and alcohol yield are improved.