A genetic medicine for treating the epithelium originated tumor, such as breast cancer, stomach cancer, is a recombinant of gene14-3-3 alpha and adenovirus. Its preparing process includes such steps as obtaining the cDNA sequence of 14-3-3 alpha by RT-PCR method, testing the sequence, externally amplifying its whole length by RCR method, severing the amplified product and the shuttle plasmid of adenovirus by specific endonuclease, transinfecting HEK293 cell strain, and encapsulating the recombinant virus.