The invention discloses a drugs combination containing extraction of grape, its principal agents are grape seed extract (the content of procyanidin is 70 -99%) 50-400 portions, grape bark extract (polyphenol content 50 -80%) 1-300 portions, total saponin(content 60 -90%) of the ginseng stem and leaf is 1-100 portions and some other excipients. Its preparation method is to weigh the main and auxiliary materials pro rate, sieve through mesh sieve 90-150 with screen mesh, then fully mix them with part of the excipients, sieve through mesh sieve with 20-50 screen mesh, then add saponin of the ginseng stem and leaf with other excipients, mix them evenly, then add the commixture adhesive, mix uniformly and dry, after they are made into granules they can be made into kinds of conventional dosage forms.