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发明公开
CN1955185A 光学活性的取代氧膦基乙酸盐及其用途 失效 - 权利终止

光学活性的取代氧膦基乙酸盐及其用途
摘要：
本发明提供一种由[(R)－[(1S)－2－甲基－1－(1－氧代丙氧基)丙氧基](4－苯丁基)氧膦基]乙酸和10，11－二氢辛可尼定生成的盐，其结构如式(1)所示。本发明还提供利用这种盐光学拆分由[(R)－[(1S)－2－甲基－1－(1－氧代丙氧基)丙氧基](4－苯丁基)氧膦基]乙酸和[(S)－[(1R)－2－甲基－1－(1－氧代丙氧基)丙氧基](4－苯丁基)氧膦基]乙酸所组成外消旋物的方法。相对于已有的拆分方法，拆分的收率和光学纯度明显提高，无需通过多次重结晶进行纯化，并且拆分剂的用量减少。
摘要（英）：

This invention provides a salt that is produced by [(R)-[(1S)-2-methyl-1- (1-keto-propoxy)propoxy](4-benzene butyl) oxygen phosphino]acetic acid and 10,11-di-H Cinchonidine, its structure is shown by formula(1). This invention also provides preparation of using this salt to optically split racemoid which consists of [(R)-[(1S)-2-methyl-1-(1-keto-propoxy)propoxy](4-benzene butyl) oxygen phosphino] acetic acid and [(S)-[(1R)-2-methyl-1-(1-keto-propoxy) propoxy](4- benzene butyl) oxygen phosphino] acetic acid. Compared with present resolution preparation, the yield and optical purity of resolution is obviously raised, it needs not recryst many times to depurate, and dosis of resolution agent is reduced.

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