A production method of refined pulp, its steps are: first removing impurities in raw materials, puffing and adding NaOH aqueous solution, warming-up and boiling with microwave, separating and removing the centrifugation solution, albefaction with ultrasound, dewatering, drying then getting products. The invention can improve the quality of refined cotton. It is energy-saving and time-saving, the equipment cleaning and operation are simple and convenient.