The invention discloses a pharmaceutical composition and process for preparation, wherein the constituents include (by weight ratio) tiopronin 1-100 parts, baikal skullcap root glycosides 5-250 parts, astragalus root 10-10000 parts. The composition can also be prepared from the following raw material herbs (by weight ratio): tiopronin 1-100 parts, baikal skullcap root glycosides 5-250 parts, astragalus root 0.1-150 parts, or tiopronin 1-100 parts, baikal skullcap root glycosides 5-250 parts, astragalus root saponins 0.1-150 parts. The pharmaceutical composition can be prepared into any clinically or pharmaceutically acceptable dose forms.