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发明授权
CN1973197B 用于进行核酸序列的扩增和检测过程的诊断系统 失效 - 权利终止

用于进行核酸序列的扩增和检测过程的诊断系统
摘要：
本发明提供用于进行核酸序列的扩增和检测过程的诊断系统，其可以是用于对含有细胞和/或粒子的流体样品进行样品制备过程的集成的芯片实验室诊断系统，该芯片实验室诊断系统包括：(a)流体样品入口；(b)裂解单元，所述裂解单元用于裂解所述流体样品所包含的细胞和/或粒子；(c)核酸提取单元，所述核酸提取单元用于从所述流体样品所包含的细胞和/或粒子提取核酸；(d)盛装裂解流体的贮存部；(e)盛装洗脱剂的贮存部，所述洗脱剂用于移去在核酸提取单元中收集的核酸；其中，所述样品入口与所述裂解单元是流体连接的，为控制二者之间流体的流动而选择性地存在阀门；其中所述裂解单元与所述核酸提取单元是流体连接的，为控制二者之间流体的流动而选择性地存在阀门；其中所述盛装裂解流体的贮存部与所述裂解单元是流体连接的，为控制二者之间流体的流动而选择性地存在阀门；和其中所述盛装洗脱剂的贮存部与所述核酸提取单元是流体连接的，为控制二者之间流体的流动而选择性地存在阀门。
摘要（英）：

An integrated lab-on-a-chip diagnostic system for carrying out a sample preparation process on a fluid sample containing cells and/or particles, the system comprising: (a) an inlet for a fluid sample; (b) a lysis unit for lysis of cells and/or particles contained in the fluid sample; (c) a nucleic acid extraction unit for extraction of nucleic acids from the cells and/or particles contained in the fluid sample; (d) a reservoir containing a lysis fluid; (e) a reservoir containing an eluent for removing nucleic acids collected in the nucleic acid extraction unit; wherein the sample inlet is in fluid communication with the lysis unit, an optional valve being present to control the flow of fluid therebetween; wherein the lysis unit is in fluid communication with the nucleic acid extraction unit, an optional valve being present to control the flow of fluid therebetween; wherein the reservoir containing the lysis fluid is in fluid communication with the lysis unit, an optional valve being present to control the flow of fluid therebetween; and wherein the reservoir containing the eluent is in fluid communication with the nucleic acid extraction unit, an optional valve being present to control the flow of fluid therebetween.

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