The invention discloses a method which extracts total soap glucoside from papermulberry fruit. It follows below steps to preparing: drying and disintegrating the papermulberry fruit and getting the papermulberry fruit powder as A material; extracting A material through mechanical squeeze or carbon dioxide supercritical extraction device, separating the papermulberry fruit peach oil and the resulting mixture is B material; extracting and refinishing B material with organic solvent and getting papermulberry fruit total soap glucoside. The invention uses mechanical squeeze or carbon dioxide supercritical extraction device to removing papermulberry fruit peach oil, then refines and extracts the material using flavouring alcohol, the got total soap glucoside extraction rate >=1.84% which is higher then other methods extraction rate (0.51%) in prior technology 3.5 times. At the same time it solves the question of effective ingredients easily lost better, raises the rate of extraction but also solves the problems of removing impurities, improving purity and decreasing cost while increasing the rate of extraction, so achieves the purpose of the invention. The extracted papermulberry fruit total soap glucoside has many effects and can be used as processing raw materials of medicines and health products.