This invention provides compositions and methods for producing low cholesterol poultry eggs using hypocholesterolemic compounds, cholesterol lowering supplements, and feeds therefrom. Preferably, this invention provides microbial statins without methyl group in C6, as shown in formula V, in order to produce low cholesterol poultry eggs. The invention allows producing low cholesterol poultry eggs without concomitant reduction of egg production by providing microbial statins, compactin and pravastatin as well as their derivatives, as cholesterol lowering components. This invention also providesmethods for producing low cholesterol poultry eggs without huge increase of production cost since the effective amount of cholesterol lowering composition containing microbial statin costs 1/120 - 1/4 of that of synthetic statin.