The utility model discloses a heat dissipation structure of a computer case, which comprises side plates of a computer case, thermovents arranged on the side plates, air guide pipes positioned on internal sides of the computer case side plates; air inlet holes of the air guide pipes are fixed on the internal side of the computer case side plates and being opposite to the thermovents; air outlet holes of the air guide pipes are covered on a radiator inside the computer case. The utility model, by adopting heat dissipation fans and air guide pipes, enhances air convection and reduces temperature within the computer case, thus having air channeling effect and good heat dissipation performance.