A pipeline lining antisepsis nipple device which is mainly used for the internal antisepsis of oil conveying pipelines and industrial water conveying pipelines and finally protecting the long conveying pipelines comprises a basic pipe (1), an anode antisepsis pipe (2) and fixed flanges (3). The anode antisepsis pipe (2) is arranged in the basic pipe (1); the fixed flanges (3) are arranged at two ends of the basic pipe (1); compared with a coating, the device has better reliability, is not easy to be separated and damaged and realizes convenient replacement and better antisepsis effect; and compared with a stainless steel lining, the device has lower cost. The pipeline lining antisepsis nipple device can react with corrosive components in the pipelines so as to reduce the content of the corrosive components in the pipelines, and has a function of sacrificing an anode and protecting a cathode so as to prevent other parts in the pipelines from being corroded, thereby achieving the aim of inside antisepsis of the pipelines and prolonging the service life of the pipelines.