The utility model relates to a key knob driving body of a security protection lock, which is characterized in that a D-shaped annular wall is formed on the circumferential wall of the axial part of a key long shaft, a stage ring is formed on the periphery of the bottom part, an interlock plate is movably sleeved on the stage ring of the key long shaft, one side of the interlock plate is provided with a pin hole, a long pin shaft is fixedly nested inside the pin hole, the center of an upper shifting fork is provided with a D-shaped groove, the D-shaped groove is sleeved on the key long shaft and is in limiting fit with the D-shaped annular wall on the circumferential wall of the key long shaft, one side of the circumferential wall of the upper shifting fork is provided with an outward-convex push flange, one end of a key short shaft is arranged on a lug boss which is matched with a through hole of the key long shaft and is nested with the key long shaft through the lug boss, a D-shaped annular wall is formed on the circumferential wall of the axial part of the key short shaft, the center of a lower shifting fork forms a D-shaped groove which is sleeved on the key short shaft and is in limiting fit with the D-shaped annular wall on the key short shaft, and one side of the circumferential wall of the lower shifting fork forms an outward-convex push flange. The key knob driving body has compact structure and convenient operation, and is applicable to the security protection locks of different types.