The utility model relates to a constant temperature and humidity console, which comprises a console surface and a constant temperature and humidity cabinet which is arranged on the console surface and is provided with a hand hole and the like, wherein the hand hole is provided with an inner isolation layer and an outer isolation layer, at least one isolation layer consists of two parallel flat elastic bands, elastically tensile ends of the flat elastic bands are tightly pressed at the outer edge of the hand hole, two transverse edges of the two flat elastic bands, which are far away from each other, both exceed the outer edge of the hand hole, and two transverse edges close to each other are collided with each other without gaps or imbricated together. When the two isolation layers both consist of the flat elastic bands, the arrangement directions of the two layers of elastic bands are perpendicular to each other; and when only one isolation layer consists of the elastic bands, the other isolation layer is a glove with the glove mouth tightly pressed at the edge of the hand hole. When drugs, reagents and other samples in the constant temperature and humidity cabinet are analyzed and hands are stretched over the hand hole for operation, the utility model can ensure the operation to be carried out at constant temperature and humidity, thereby improving the accuracy and reproducibility of sample analysis.