The utility model discloses an automatically program controlled amplifier used for bottom hole wireless data transmission of coiled tubing operation, which belongs to the technique field of bottom hole wireless data transmission equipment. The automatically program controlled amplifier includes an amplifier for amplifying an acoustic wave signal introduced by an acoustic wave receiving device; an A/D converter for collecting the acoustic wave signal after amplification by the amplifier, and performing analog-to-digital conversion to the acoustic wave signal; an amplifying proportionality controller for increasing or decreasing the amplifying proportionality of the size of the acoustic wave signal; and a central program controlled processing module for determining and controlling the amplifying proportionality of the amplifier. By means of the automatically program controlled amplifier, on one hand, the signal amplifying proportionality may be automatically regulated according to the size of a main signal so as to ensure the size of the main signal after amplification to meet the requirement of a decoding device; on the other hand, the amplifying proportionality will not be automatically regulated when there is no main signal, such that an interfering signal will not be amplified greatly due to the weak signal during a transmission intermission period.