The utility model discloses a programmable zoning control device based on a coal-mine safety monitoring system, which comprises a human-machine interface. The human-machine interface is connected with a controller through a data line; the inside of the controller is provided with a programmable controller and an interface circuit; and the interface circuit is provided with a constant-current diode. The advantages of the programmable zoning control device are as follows: output way can be flexibly combined and controlled; a key can control a device or a plurality of devices, and the control logic can be freely combined through the programmable controller; the using range is wide, control commands are received through the device monitored and imitated by a sub-station opening/stopping the sensor; the device can be combined with any coal-mine safety monitoring system; software and hardware of the existing coal-mine safety monitoring system are not changed; and the human-machine interface is used for receiving commands and the operator can realize control through directly clicking the human-machine interface.