The utility model discloses spray-proof high-pressure polish rod sealing equipment comprising a sealed lubrication cavity and a drain pipe extending outwards from the side wall of the sealed lubrication cavity, and a polish rod penetrates out of the top of the sealed lubrication cavity. The spray-proof high-pressure polish rod sealing equipment also comprises an automatic spray-proof device comprising a spring, a valve seat, a valve ball and a sealed ball seat, wherein the spring is installed in the drain pipe, one end is fixed on a drain valve at the outlet of the drain pipe, the valve seat is fixed on a free end, and the valve seat provides elasticity to cause the valve ball to be in contact with the moving polish rod. The sealed ball seat is positioned at the top of the sealed lubrication cavity and has a shape which causes the valve ball to block the exposed hole at the top of the sealed lubrication cavity when the polish rod is broken and disconnected. After the polish rod of a pumping well mouth is broken and disconnected, the polish rod sealing equipment can automatically close an oil-gas flow path, seal the well mouth and prevent raw oil and natural gas in an oil well shaft and a ground pipeline from ejecting out of the well mouth, thus preventing pollution, and avoiding great potential safety hazards in oil extraction fields.