The utility model provides a natural gas hydrate and drilling fluid interaction simulating test device. The device comprises a circulating device which is arranged in a heat-preserving box and an experimental cylinder body; the circulating device comprises two circulating buckets which are fixed on a soleplate of the heat-preserving box; rubber sleeves are respectively arranged in the circulating buckets; each circulating bucket is provided with an upper bottom tray and a lower bottom tray, and both the upper bottom tray and the lower bottom tray are connected with the circulating buckets in a sealing way; the experimental cylinder body comprises a pressure chamber cylinder; the pressure chamber cylinder is provided with an upper end cover and a lower end cover; both the upper end cover and the lower end cover are connected with the pressure chamber cylinder in a sealing way; the pressure chamber cylinder is provided with a plurality of sound wave probes; the upper end cover is provided with a piston, and the piston is connected with the pressure chamber cylinder and the upper end cover in a sealing way; a drilling fluid feeding passage and a drilling fluid outputting passage are arranged in the piston; and the drilling fluid feeding passage is communicated with a connecting sleeve on one of the circulating buckets, and the drilling fluid outputting passage is communicated with a connecting sleeve on the other one of the circulating buckets.