The utility model relates to a multi-stage pressure filtration and slide pressurization continuous solid-liquid separation machine which solves the problem that at present, solid-liquid separation equipment which occupies small area has high production efficiency does not exist. The solid-liquid separation machine comprises a machine frame, a feeding device, an upper filter belt, a lower filter belt, a press area and a driving device, and is characterized in that the press area comprises a plurality of press units adopting vertical structures; each press unit comprises a press block, an upper press roll, a lower press roll, a slide rubber belt and a transmission belt, wherein the slide rubber belt is wound outside the press block, the upper press roll and the lower press roll are respectively positioned above and below the press block, the transmission belt is wound outside the upper press roll, the slide rubber belt and the lower press roll; a clearance is formed between any two adjacent press units, and the width of the clearance is reduced gradually from an inlet to an outlet; and the upper filter belt and the lower filter belt overlap and then sequentially wind through each clearance. The solid-liquid separation machine has the advantages of reasonable structural design, small occupied area and high solid-liquid separation efficiency, can adapt to dehydration of viscous and smooth material and operates continuously.