The utility model discloses an anti-seismic steel window frame of a masonry house. The anti-seismic steel window frame comprises a top frame, a bottom frame, two upright posts, a transverse support and two oblique supports. The anti-seismic steel window frame is characterized in that the top frame, the bottom frame, the upright posts, the transverse support and the oblique supports are welded into the closed window frame by profile steel, a connector fixed with a wall of the masonry house is arranged on each of four sides of the steel window frame, and the connectors are angle steel, flat steel or bolt connectors. The anti-seismic steel window frame of the masonry house has certain rigidity; for the masonry house with large hole forming area of a wall window, displacement and dislocation of the wall around the window can be effectively restrained, the rigidity, the ductility and the anti-shearing bearing capacity of the wall around the window are greatly improved, the negative influence of a torsional effect caused by uniform rigidity of the front and rear longitudinal walls under the action of seism is reduced, and the integral anti-seismic performance of the masonry house is improved; and the anti-seismic steel window frame is simple in structure and convenient to construct, and has practicability.