The utility model provides an intelligent substation simulation system. The system comprises a real-time digital simulation device, a merging unit, an intelligent terminal, a photoelectric isolator, a protector and a monitor, wherein the real-time digital simulation device simulates a practical power system and outputs secondary voltage and a current signal to the merging unit; the real-time digital simulation device outputs a potential signal and converts the potential signal into a node signal by the photoelectric isolator, and then the node signal is output to the intelligent terminal; the merging unit and the intelligent terminal respectively sends messages and outputs the messages to the protector in an optical fiber jumper manner; the protector generates a protection action signal according to the messages and outputs the protection action signal to the monitor; the monitor monitors the states of devices in the simulation system according to the protection action signal; the protector generates a trip signal according to the messages and sends the trip signal to the intelligent terminal; and the intelligent terminal trips off corresponding circuit breaker modules in the real-time digital simulation device according to the trip signal.