The utility model relates to an intelligent programmed operation system based on a substation panoramic information platform. The intelligent programmed operation system is formed in a manner that a digital monitoring computer (2) is connected with a scheduling operation instruction sending server (1) and a panoramic information platform server (3); the digital monitoring computer (2) is further connected with a substation telecontrol device (6) through a unidirectional physical isolation device (4) and an IEC104 protocol conversion device (5); and the substation telecontrol device (6) is connected with a substation distance detection and control device (7). According to the utility model, the safety of one-button programmed operation of an intelligent substation is improved by using intelligent judgment and analysis after the data processing of the panoramic information platform in substitution of the artificial judgment on weather conditions, equipment operation conditions and in-site work conditions in the conventional substation equipment operation process.