The utility model discloses a frequently opened and closed stop valve. The frequently opened and closed stop valve comprises a driving mechanism, a driving connecting piece, a valve body connecting piece, a valve core and a valve core sealing element, wherein the driving mechanism is connected with the driving connecting piece; the driving connecting piece is connected with the valve body connecting piece; a piston rod of the driving mechanism is connected with the valve core; the valve core sealing element is arranged at the bottom of the valve core; and the driving connecting piece and the valve body connecting piece respectively have holes for the piston rod and the valve core to pass through. Compared with the prior art, the frequently opened and closed stop valve provided by the utility model has a simple structure, can be dismantled, replaced and maintained by users, and is convenient to process and maintain, thus solving the problem of high cost caused by frequent replacement of the valve core sealing element of the stop valve.