The utility model discloses a machine head turnover protection device for an industrial sewing machine. The machine head turnover protection device includes a machine head turnover signal acquisition module, a microcontroller module, a servo motor drive control module and an operation panel module as well as a roll ball switch or a mercury switch, wherein the output end of the machine head turnover signal acquisition module is connected with the signal input end of the microcontroller module; the microcontroller module is bidirectionally connected with the servo motor drive control module and the operation panel module respectively; the servo motor drive control module is connected with a servo motor of the sewing machine; the signal output end of the roll ball switch or the mercury switch is connected with the input end of the machine head turnover signal acquisition module; the roll ball switch or the mercury switch is arranged in the machine head of the sewing machine; and the roll ball switch or the mercury switch and a sewing machine table board form an angle of larger than 10 degrees. According to the machine head turnover protection device, the defect of the machine head turnover protection of the conventional sewing machine is overcome, the reliability of the machine head turnover protection of the sewing machine is guaranteed, the safety of repairers and equipment is guaranteed, and the potential safety hazard is avoided.