Disclosed is a high temperature resistance anti-interference compensation cable, comprising multiple insulating wire cores formed by intertwisting multiple strands of conductors, wherein the multiple insulating wire cores are intertwisted to form a cable core; the cable core is wrapped by a fluoroplastic insulating layer; the insulating layer is internally filled with glass fiber ropes and is coated by a separating layer; and the separating layer is sequentially coated by a tin-coated copper filament braiding sub-shielding layer, an inner sheath, a tin foil sleeve, a copper strip coated total shielding layer, and an outer sheath. The high temperature resistance anti-interference compensation cable adopts multi-layer sheath and insulation, thereby avoiding the influence of the high temperature upon the cable conductor, meeting the demand of compensating cable connected with a high temperature thermocouple, and ensuring the normal operation of the cable under the high temperature with the transmission of the precise signals. Meanwhile, the high temperature resistance anti-interference compensation cable adopts a tin foil sleeve to cooperate with the double-layer shield, thereby effectively improving the anti-interference capability of the compensation cable and ensuring the safe and stable operation of the compensation cable.