The utility model relates to the technical field of well drilling operation tools, in particular to a directional well wire twining-preventing device. The directional well wire twining-preventing device comprises a middle connecting sleeve, a power transmission spline barrel and a power transmission spline shaft, wherein the inner side of the lower portion of the middle connecting sleeve and the outer side of the upper portion of the power transmission spline barrel are fixedly arranged together, a shaft shoulder is arranged at the outside of the lower portion of the power transmission spline shaft, the bottom of the power transmission spline barrel is erected on the shaft shoulder, inner splines are distributed at the inner side of the power transmission spline barrel, and outer splines matched with the inner splines are distributed at the outer side of the power transmission spline shaft located above the power transmission spline barrel. The directional well wire twining-preventing device is reasonable and compact in structure and convenient to use. Through the looseness and meshing of the inner splines and the outer splines, the wired cables are prevented from twining without the need of a lifting instrument when the directional well wire twining-preventing device is installed. The directional well wire twining-preventing device is more convenient and rapid to install, time-saving and labor-saving in the installation process.