A screw hole enhanced type connecting structure for large-span laminated wood columns and beams comprises a metal connecting piece (1). The metal connecting piece (1) is composed of a base plate and an insertion block, the base plate makes contact with one face of a laminated wood column (2) and is connected with a base plate on the other side face of the laminated wood column (2) through bolts so that the metal connecting piece (1) can be fixed to the laminated wood column (2), the insertion block is inserted into an insertion groove (4) in the end portion of a laminated wood beam (3), and the insertion block is connected with the laminated wood beam (3) through connecting bolts. The screw hole enhanced type connecting structure is characterized in that GFRP tubes (6) are in glue joint into through holes in the end portion of the laminated wood beam (3), wherein connecting bolts can be arranged in the through holes in a penetrating mode; GFRP tubes (6) are in glue joint into bolt holes in a node area, connected with the laminated wood beam, of the laminated wood column (2). The screw hole enhanced type connecting structure can improve carrying capacity, lighten concentrated distribution of stress and avoid damage to connecting nodes, and the size of the connecting structure and construction costs can be reduced beneficially.