An opening-out unlocking mechanism of a mechanical-electrical integration central centralized control door lock comprises an outer unlocking arm, an operation arm and a releasing arm, wherein the outer unlocking arm is provided with a first rotation center hole and a power output end port, the operation arm and the releasing arm are provided with second rotation center holes which are concentric, the outer unlocking arm is provided with a long round groove, the operation arm is provided with a riveting pin or a boss, and the riveting pin or the boss of the operation arm is located in the long round groove of the outer unlocking arm; when the outer unlocking arm rotates around the first rotation center hole, the operation arm is driven through the riveting pin or the boss on the operation arm to rotate around the second rotation center holes; the releasing arm is provided with a stirring block and a curve receding structure located above the long round groove. According to the opening-out unlocking mechanism, in a rotation process of the outer unlocking process, the length of the position producing sliding friction is small is short, abrasion will not occur easily, the opening-out unlocking mechanism has little influence on changes of the route and unlocking force of a lock body after being used for a long time, and therefore the service life of the door lock is prolonged, and reliability is improved.