The utility model provides an air mist heat exchange device. The air mist heat exchange device comprises a heat exchange box body, wherein the heat exchange box body is provided with a water inlet pipe, a water outlet pipe, an air inlet pipe and an air outlet pipe; the water inlet pipe stretches into the heat exchange box body, the water inlet pipe positioned in the heat exchange box body is provided with multiple distributive pipes which are vertically arranged, and the end part of each distributive pipe is provided with a spray nozzle. The mist heat exchange device provided by the utility model has the advantages that the structure is simple, the assembly and maintenance are convenient, the heat exchange process is simple and rapid, and the convection contact of the air and the mist can realize the heat conduction; the air after heat exchange can discharge from an air outlet, and the water after heat exchange penetrates through a water seepage isolated layer to discharge from a water outlet; the temperature sensors at the air outlet and the air outlet can detect the temperatures of the air and water after heat exchange, an electric controller can analyze and detect the temperature values of the air and the water and can send an instruction to adjust the opening quantity of an air inlet air volume regulating valve and an air outlet air volume regulating valve after analysis and calculation, the full heat exchange of the air and the water is realized, and the efficiency of the heat exchange device is optimum.