The utility model discloses a measurement system based on digital isolation. The system comprises a group of measurement circuits which are in one to one corresponding connection with a group of sensor output signals. Each of the measurement circuits is formed by the order connection of an input conditional circuit, an amplifier circuit, an AD conversion circuit and a digital isolation circuit. The output end of each measurement circuit is connected with the signal input end of an FPGA used for digital signal framing, and the signal output end of the FPGA is connected with a main controller. The measurement system is provided with multiple paths of measurement circuits, the independent input conditional circuit, amplifier circuit, AD conversion circuit and digital isolation circuit are employed by each path of measurement circuit, thus the isolation between the measurement circuits is realized, and the normal working of other part of circuits is not influenced by the damage of any path of measurement circuit, the FPGA is utilized by the output end of each measurement circuit to carry out framing on each path of data according to an established protocol and send the data to a CPU, the burden of the CPU is reduced, and the operation speed is raised.