Disclosed is an off-centering underwater casing head hoisting frame. The hoisting frame comprises hangers, a support framework, a balancing weight and fitting pins. The support framework comprises a connector and I-beams. Four bearing I-beams are connected to form a rectangular frame. The four bearing I-beams are connected to the connector of the support frame. Two I-beams are led out from centers of the long edges of the rectangular frame to be connected with the support frame on the connector. The connector is fixed on the support frame. The outer wall of the connector is provided with eight slots for the fitting pins. The fitting pins are threadingly connected with the outer wall of the connector and pass through the outer wall of the connector. The hangers are respectively disposed at four opposite angles of the support frame. The balancing weight is disposed on four edges of the support frame. The hoisting frame is compact in structure, simple in operation, safe and reliable, and fully meets the requirements of safe and steady hoisting of an irregular, off-centering and large-quality underwater casing head in deep ocean drilled well operations.