The utility model discloses a novel computer USB interface protection strip. The novel computer USB interface protection strip comprises a protection strip body and a USB interface. The protection strip body is cross-shaped and is composed of a main handle and auxiliary handles, wherein the auxiliary handles are respectively arranged on the two sides of the main handle. An open hole is formed in the main handle, and a USB connector is inserted into the open hole. The novel computer USB interface protection strip can block the computer USB interface and has the dust prevention and water resistance effect, thereby guaranteeing the safety of a computer effectively, being stable to operate, small in size and convenient to carry and having certain application and popularization value.