The utility model relates to a large-scale data acquisition business multi-group distribution system, belongs to the message distribution system and solves a problem that data access technology configuration of a large-scale business information system in the prior art can not realize stable transition to cloud data service. The large-scale data acquisition business multi-group distribution system comprises a gateway cluster comprising multiple communication gateways, a front-end communication cluster comprising multiple front-end communication machines and a business processor cluster comprising multiple business processors, wherein the front-end communication machines are connected with the gateways, the business processors are connected with the front-end communication machines, the front-end communication machines are used for carrying out scheduling and uplink/downlink message storage processing, the business processor cluster is divided into multiple business processor groups, the front-end communication machines are provided with management units which correspond to the business processor groups in number, the management units are mutually independent, and each management unit comprises a buffer memory module, a message distribution scheduling module and a link management module. The large-scale data acquisition business multi-group distribution system realizes data multi-group distribution and multi-target warehousing and improves distribution efficiency.