The utility model discloses a liquid crystal screen cleaning eraser which comprises a box body and sponge connected with the box body. An injection port is arranged on the upper part of the box body, a left side wall and a right side wall of the box body are respectively provided with buttons, and a water outlet spray head is arranged below the box body. The liquid crystal screen cleaning eraser is modified on the basis of a traditional liquid crystal screen cleaning mode, and the using habit of separating existing cleaning detergents and wiping cloth on the market is changed to one-time injection and many-times use. When the liquid crystal screen cleaning eraser is in use, both hands are liberated, operation can be finished only by one hand, the buttons on two sides are pressed down through the thumb and the index finger, the detergents can wet the surface of the ultrafine fiber wiping cloth through the water outlet spray head, the cleaning area is increased, the process is more efficient and convenient, repeated spraying is not needed, and the ultrafine fiber wiping cloth on the lower portion and the sponge can be used in a replaceable mode and are economical and environmentally friendly.