The utility model relates to the technical field of machine tool fixtures, and in particular relates to a workpiece inclined hole machining device, wherein a workpiece locating fixture and a drill plate support are arranged on the fixed bracket; a drill plate is mounted on the drill plate support through a revolving shaft and can be opened by rotation; the workpiece locating fixture comprises a workpiece near-end locating pin, a workpiece far-end locating in and a pressing plate; the center of the workpiece near-end locating pin is provided with a workpiece compression shaft which extends in a cantilever type; the workpiece compression shaft is parallel to the revolving shaft of the drill plate; the pressing plate applies axial compression force to a workpiece sleeving on the workpiece near-end locating pin through a nut mounted on the workpiece compression shaft; the drill plate is positioned above the workpiece compression shaft. The workpiece inclined hole machining device has the advantages of simple structure, convenience for use, easiness in production and repairing and low in cost, being capable of completely locating the workpiece to be machined, being accurate in locating, reliable in clamping and difficult to slip when in machining, and good in reliability and applicability, and greatly improving machining quality and production efficiency.