Provided is a vehicle-mounted decontamination machine. A decontamination machine frame is provided with A burner assembly, an electric control box located on one side of the burner assembly, an air supply oil feeding device, a centrifugal pump and an oil tank. The air supply oil feeding device and the centrifugal pump are arranged in the decontamination machine frame, sequentially located below the electric control box and electrically connected with the electric control box, and the oil tank is arranged in the decontamination machine frame and located below the burner assembly. The oil inlet end of the air supply oil feeding device is connected with an oil outlet of the oil tank, the oil outlet end of the air supply oil feeding device is connected with an oil inlet of the burner assembly, the water inlet end of the centrifugal pump is connected with an external water inlet through a pipe, the water outlet end of the centrifugal pump is connected with the water inlet end of the burner assembly, a water outlet of the burner assembly is connected onto a decontamination machine water outlet formed in the lower portion of the decontamination machine frame through a pipe, and the decontamination machine water outlet is connected to the water inlet end arranged on a decontamination pipe. The vehicle-mounted decontamination machine can provide stable low-pressure heated decontamination water, and can be applied to emergency infectious disease fields for conducting cleaning and disinfection on personnel, prevent further diffusion of pollution and increase emergency security level.