The utility model relates to a water leakage prevention monitoring device which comprises a main station computer, monitoring devices from first to Nth, a short message module, a mobile phone and a local area network. The first monitoring device comprises a first sub station computer U11, a first interface module U12, a first microcontroller U13 and on-site monitoring units from first to mth UNIT1 to UNITm. The monitoring devices from the first to the Nth share the same structure. The water leakage prevention monitoring device provided by the utility model has the advantages that real-time monitoring can be carried out on a monitored point; if water leakage is found, an acousto-optic alarm can be timely given; a short message is sent to staff, so that alarm information can be sent to the staff in the first time late at night and in holidays; communication is carried out between each monitoring device and the main station computer based on the local area network in a building, which saves the laying of a large number of signal cables; and in addition, the device is provided with a visual interface, thus the staff can remotely observe whether water leakage exists at the monitored point through a computer screen.