The utility model relates to a ground wire interlocking isolation switch device. The ground wire interlocking isolation switch device is characterized by including a housing; a TM card reader is disposed in the housing; the TM card reader is connected with a TM sensing head on the housing; the TM card reader, through a server, is further connected with a motor installed in the housing; an output shaft of the motor, through a transmission mechanism, is connected with a locking hole of a five-prevention lock (4) installed in the housing so as to unlock or lock the five-prevention lock (4); and a spring bolt of the five-prevention lock (4) stretches out to the outside of the housing. Trials prove that with the adoption of the ground wire interlocking isolations witch device, mis-closing an isolation switch in a case that a ground wire exists can be effectively prevented, and thus hidden safety hazards are reduced and accidents are prevented.