The utility model relates to an instrument box which comprises a box body and a box cover. The box body is provided therein an air chargeable cushion. When the cushion is charged with air, it becomes an air cushion box. The air cushion box is provided at the top with an opening portion. A vibration reducing spring is mounted between the box body and the air cushion box to reduce vibrations. The air cushion is a rubber or canvas made air cushion. In the instrument box provided by the utility model, an air chargeable cushion is arranged inside the instrument box body and between the air cushion and the box body is arranged a vibration reducing spring to resolve the vibrating problem. The introduction of a draw ring also makes the instrument box convenient to transport, mount, place and keep so that the instrument box can be used to hold and transport a large scale precision instrument with.