The utility model discloses an indoor large temperature difference area heat insulation and sound insulation heat retaining panel structure which comprises flexible heat retaining rubber bars (1), clamp type keels (2), water discharge grooves (3) and a heat insulation and sound insulation heat retaining panel (4). The clamp type keels (2) are of a U-shaped groove structure, one clamp type keel (2) is mounted at the upper end of the heat insulation and sound insulation heat retaining panel (4), the other clamp type keel (2) is mounted at the lower end of the heat insulation and sound insulation heat retaining panel (4), the flexible heat retaining rubber bars (1) are arranged between the top end face of the heat insulation and sound insulation heat retaining panel (4) and the U-shaped groove bottoms of the clamp type keels (2), and the water discharge grooves (3) are fixed to the clamp type keels (2) through screws (5). Clamp teeth are arranged on the inner side faces of the U-shaped grooves of the clamp type keels (2). The cross sections of the water discharge grooves (3) are in a U shape. The indoor large temperature difference area heat insulation and sound insulation heat retaining panel structure is firm in mounting, field processing and mounting are easy, construction quality is high, and the problems of the slow field progress, adhesive pollution and the like can be solved.