The utility model relates to an anti-misoperation protective device of an electric power switching knob, belonging to the technical field of overhaul tool equipment in the electric power industry. The anti-misoperation protective device comprises an installation substrate, a fixed sleeving fixedly arranged on the installation substrate, a push rod device movably sleeved in the fixed sleeving, a latching module fixedly arranged at the lower end of the push rod device and a caution board arranged on the push rod. The installation substrate is fixedly provided with a caution board casing used for shielding the caution board. The latching module is inverted U-shaped with an opening downwards. The fixed sleeving is provided with a jackscrew used for restricting the push rod device from freely moving up and down. The anti-misoperation protective device provided by the utility model is simple in structure and convenient and practical. Through the push rod device used for pushing the latching module downwards, meanwhile the caution board moves downwards, to avoid the caution board casing. Display is arranged outwards, and the latching module moves downwards to block the switching knob in a U-shaped groove, so that the switching knob is effectively restricted from being pressed down, and security measures are forced to realize.