The utility model provides a high-voltage cabinet protection monitoring system for an unattended substation. The high-voltage cabinet protection monitoring system comprises a local module installed on a high-voltage cabinet body and a remote control module connected with the local module, wherein the local module comprises a monitoring unit and an alarm unit; the remote control module comprises a data processor, and a server and a memory which are connected with the data processor; and the memory is connected with the alarm unit. The high-voltage cabinet protection monitoring system can integrate remote monitoring and security alarm, and extends function scopes of remote monitoring and security alarm respectively; with regards to monitoring, the high-voltage cabinet protection monitoring system can be connected with a network database to form a cloud monitoring and alarm network; with regards to security alarm, the high-voltage cabinet protection monitoring system can warn all kinds of physical damages to the high-voltage cabinet body in advance, and can be interconnected with a network among high-voltage cabinets directly to form an integrated monitoring and early-warning security platform, so that the effectiveness and real-time performance of monitoring alarm are better.