The utility model discloses chronic disease early stage electrophysiology detecting equipment which comprises a plurality of electrodes, a detecting device and a signal source. The electrodes are arranged on measurement parts marked according to chronic disease early stage electrophysiology detecting items. The detecting device comprises a sending module used for sending control signals to the signal source, a collecting module used for collecting resistance values, obtained through measurement signals, between the electrodes on the measurement parts corresponding to all sets of human body resistance networks, a microprocessor used for determining an electrophysiology detecting result and outputting the electrophysiology detecting result to a display module, and the display module used for receiving and displaying the electrophysiology detecting result. The utility model further discloses a corresponding system. By means of the chronic disease early stage electrophysiology detecting equipment and system, the lesion or health condition of human body local body tissue can be measured in a targeted mode, and the chronic disease early stage electrophysiology detecting result is made to be more accurate; furthermore, due to the fact that a measured person does not need to exercise a lot before measurement, the measurement efficiency is high.