The utility model relates to an omeprazole sodium bicarbonate in-tablet tablet. The omeprazole sodium bicarbonate in-tablet tablet sequentially comprises an omeprazole tablet core, a sodium bicarbonate layer, an omeprazole layer and a sodium bicarbonate shell wrapping the omeprazole layer. Omeprazole is made into a small tablet serving as the tablet core, and for promoting quick release of the omeprazole, the tablet core is not coated, sodium bicarbonate and auxiliary materials are made into large tablets, and the tablet core is wrapped by the large tablets. By the adoption of the technical scheme, the omeprazole sodium bicarbonate in-tablet tablet has the advantages that sodium bicarbonate is firstly in contact with gastric acid to be neutralized, then the omeprazole is released, and the omeprazole is completely released in an alkaline environment. The purpose can be achieved by using compressed omeprazole tablets, and the situation that alkaline environment is damaged due to too long time is avoided. The omeprazole sodium bicarbonate in-tablet tablet is long-acting and is high in release effect.