The utility model discloses a precision macro-motion parallel positioning system in micro-nano operating environment. The system comprises a machine body, a calibrating device, and a control device which are connected successively. The machine body comprises a pedestal and more than three groups of same ultrasonic motor-driven branched chains and movable platform. The calibrating device is used for calibrating the actual value of a kinematics parameter, feeding back a joint motion position, and correcting the original point of the movable platform. The control device is used for processing module signals, making corresponding treatment, and driving the machine body to move along a predetermined locus. The precision macro-motion parallel positioning system in micro-nano operating environment eliminates a disadvantage of a conventional electromagnetic motor, decreases influences of nonlinear factors such as the friction, the gaps, and the elastic deformation of additional mechanisms, has characteristics of being free of gap, high in rigidity, compact in structure, capable of eliminating assembling errors and dimension errors, and suitable for micro-nano operating environment, achieves submicron-order positioning precision and millimeter-order stroke, and can be applied to a macro-micro combined positioning table.